Alloimmunité - Auto-immunité - Transplantation
Présentation
Equipes de recherche
Equipe 1 - Différentiation lymphocytaire et homéostasie dans l’allo et l’autoimmunité
Antoine Toubert
Groupe 1 – Matthieu Allez – Maladies inflammatoires du tube digestif
Groupe 2 – Ryad Tamouza - Immunogénétique
Equipe 2 - Régulation de la réponse immunitaire allogénique lors d’une transplantation rénale
Nuala Mooney
Equipe 3 - Greffes de cellules souches hématopoietiques
Gérard Socié
Equipe 4 - Physique du cytosquelette et de la morphogenèse
Manuel Théry
Equipe 5 - NK et Cancer
Anne Caignard
Equipe 6 - INKT pathologies
Kamel Benlagha
[hal-02173642] A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia
Date: 8 avr 2024 - 18:34
Desc: [...]
[cea-04557509] Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
Date: 24 avr 2024 - 12:34
Desc: Background Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in the pathophysiology. Association between pattern-recognition receptor coding genes and BD had been previously reported. However, potential interactions with history of pathogen exposure are yet to be explored. Methods 138 BD patients and 167 healthy controls were tested for serostatus of Toxoplasma gondii, CMV, HSV-1 and HSV-2 and genotyped for TLR2 (rs4696480 and rs3804099), TLR4 (rs1927914 and rs11536891) and NOD2 (rs2066842) polymorphisms (SNPs). Both the pathogen-specific seroprevalence and the TLR/NOD2 genetic profiles were compared between patients and controls followed by modelling of interactions between these genes and environmental infectious factors in a regression analysis. Results First, here again we observed an association between BD and Toxoplasma gondii (p = 0.045; OR = 1.77; 95 % CI 1.01–3.10) extending the previously published data on a cohort of a relatively small number of patients (also included in the present sample). Second, we found a trend for an interaction between the TLR2 rs3804099 SNP and Toxoplasma gondii seropositivity in conferring BD risk (p = 0.017, uncorrected). Conclusions Pathogen exposure may modulate the influence of the immunogenetic background on BD. A much larger sample size and information on period of pathogen exposure are needed in future gene–environment interaction studies.
[inserm-03118650] Natural killer cell licensing after double cord blood transplantation is driven by the self-HLA class I molecules from the dominant cord blood
Date: 22 jan 2021 - 13:36
Desc: [...]
[hal-01347594] Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery
Date: 21 juil 2016 - 12:57
Desc: Objectives: Preventing postoperative recurrence after ileocolonic resection (ICR) for Crohn's disease (CD) is challenging. Defining the disturbances of the microbial composition and community structure after ICR and their link with early disease recurrence is crucial. Design: Microbiota composition (fingerprinting and 16S rDNA sequencing) and community structure (correlation networks of bacterial species) were assessed from ileal mucosa sampled in 20 patients undergoing ICR and 6 months later during endoscopy from above (neoterminal ileum) and below (subanastomotic colon) the surgical anastomosis. Results: ICR had a dramatic effect on gut microbial ecosystem. At surgery, CD mucosa harboured a dysbiotic microbiota with high proportions of α/β Proteobacteria and Bacilli. Six months later, half of the patients had recurrent lesions at ileocolonoscopy and presented higher numbers of Lachnospiraceae. Recurrence of endoscopic lesions was associated with enrichment in Enterococcus durans while patients in remission had increased proportions of Dorea longicatena and Bacteroides plebeius. Structural differences were striking between recurrence and remission microbiota; while the microbiota of patients with CD recurrence exhibited a loose community structure, the microbiota of patients in remission displayed communities that were robustly correlated to each other. Microbiota colonising the neoterminal ileum and subanastomotic colon 6 months after ICR only differed in patients with recurrence. Conclusions: ICR modifies the gut microbiome. Remission after 6 months was associated with homogenous bacterial distribution around the anastomosis. Community structure and bacterial networks highlight target species, including Faecalibacterium prausnitzii and Ruminococcus gnavus, which may allow precise modulations of the overall microbial ecosystem towards remission pattern.
[hal-01362680] Matching for the non-conventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD
Date: 9 sep 2016 - 11:40
Desc: [...]
Autres contacts
UMR 1160
Unité mixte de recherche 1160 - Alloimmunité - Autoimmunité - Transplantation
Directeur : Antoine Toubert
Hôpital Saint-Louis
1 avenue Claude Vellefaux
Institut Universitaire d'Hématologie